Hydradao聲稱其研究人員能夠使用一種新穎的技術來修復大鼠的棘突

在5月5日的帖子中，分散的科學（DESCI）項目Hydradao說，其研究項目之一導致“使脊椎完全轉移的大鼠能夠再次行走”。

Decentralized autonomous organization HydraDAO claims that its researchers were able to use a novel technique to repair severed spines in rats.

分散的自治組織Hydradao聲稱其研究人員能夠使用一種新穎的技術來修復大鼠的棘突。

Decentralized science (DeSci) project HydraDAO said that one of its research projects resulted in rats who had their spines fully transected being able to walk again. More notably, recovery from surgery took five days.

去中心化科學（DESCI）計劃Hydradao說，其中一項研究項目導致使脊柱完全轉移的老鼠能夠再次行走。更值得注意的是，從手術中恢復了五天。

The project in question is the Dowell spinal fusogens project led by Michael Lebenstein-Gumovski, which had 380,700 USDC donated to it. The dedicated HydraDAO page describes it as follows:

所討論的項目是由邁克爾·勒本斯坦·古莫夫斯基（Michael Lebenstein-Gumovski）領導的Dowell Spinal Fusogens項目，該項目捐贈了380,700 USDC。專用的Hydradao頁面將其描述如下：

A team of neuroscientists led by Dr. Michael Lebenstein-Gumovski developed a unique technology for fusing spinal cord tissue after complete transection. The project is named after the famous neurosurgeon Dr. Charles Dowell, a pioneer in spinal cord injury research.

由邁克爾·勒本斯坦·及多夫斯基（Michael Lebenstein-Gumovski）博士領導的一組神經科學家團隊開發了一種獨特的技術，用於融合脊髓組織後，完成後進行了融合。該項目以著名的神經外科醫生查爾斯·道爾（Charles Dowell）博士的名字命名，他是脊髓損傷研究的先驅。

The technology is based on a special compound called PEG-chitosan, which is a derivative of polyethylene glycol (PEG) and chitosan, a biopolymer found in crustacean shells. This compound has been studied for its ability to fuse cell membranes, which is crucial for repairing severed nerve fibers.

該技術基於一種稱為PEG-Chitosan的特殊化合物，該化合物是聚乙烯甘油（PEG）和殼聚醣的衍生物，這是甲殼類殼中發現的生物聚合物。該化合物的研究能力融合了細胞膜，這對於修復切開的神經纖維至關重要。

The researchers also developed a method for rapidly solidifying the PEG-chitosan compound using light, which allows them to create a strong scaffolding that can hold the spinal cord together as it heals.

研究人員還開發了一種使用光快速凝固PEG-Chitosan化合物的方法，這使他們能夠創建強大的腳手架，可以將脊髓固定在一起。

In addition, they used several neuroprotection techniques, such as local hypothermia and cellular death inhibitors, to minimize damage to the nerve tissue during surgery.

此外，他們使用了幾種神經保護技術，例如局部體溫過低和細胞死亡抑製劑，以最大程度地減少手術中對神經組織的損害。

The results of the research are promising. Pigs that had their spines completely severed and were treated with the technology developed by Dr. Lebenstein-Gumovski's team recovered mobility within two months. The researchers are now working to further develop the technology and hope to begin human testing soon.

研究結果是有希望的。豬的豬完全切斷，並接受了勒本斯坦·古莫夫斯基博士在兩個月內恢復流動性的技術。研究人員現在正在努力進一步開發該技術，並希望盡快開始人類測試。

Fusogens are chemicals capable of fusing cell membranes and have long been researched as a means to reconnect severed nerve fibers. One such chemical is polyethylene glycol (PEG), which was shown to promote membrane fusion and seal axonal membranes in other research.

熔融劑是能夠融合細胞膜的化學物質，長期以來一直研究為重新連接切斷的神經纖維的一種手段。一種這樣的化學物質是聚乙烯乙二醇（PEG），該乙二醇（PEG）在其他研究中被證明可促進膜融合和密封軸突膜。

Lebenstein-Gumovski's team adds a biopolymer from crustacean shells called chitosan, resulting in a PEG-chitosan compound dubbed neuro-PEG. This compound is also photopolymerizable, meaning it can be rapidly solidified using light.

Lebenstein-Gumovski的團隊增加了一個名為Chitosan的甲殼類動物的生物聚合物，從而產生了一個名為Neuro-Peg的Peg-Chitosan化合物。該化合物也是可光聚合的，這意味著它可以使用光快速固化。

This presumably allows for creating a solid scaffolding that can weld the spinal cord more permanently than liquid PEG-based solutions. Dowell also implements neuroprotection techniques such as localized hypothermia and cellular death inhibitors to prevent further damage to nerve tissue.

據推測，與基於液體PEG的溶液相比，這可以創建可更永久焊接脊髓的實心腳手架。 Dowell還實現了神經保護技術，例如局部體溫過低和細胞死亡抑製劑，以防止對神經組織的進一步損害。

A 2023 research paper by Gumovski published in the peer-reviewed scientific journal Surgical Neurology International claimed that pigs treated with the compound recovered mobility in two months. The study’s conclusion reads:

Gumovski的2023年研究論文發表在同行評審的科學雜誌《外科神經病學》國際雜誌上聲稱，用化合物恢復了兩個月的流動性。該研究的結論是：

The results of this study demonstrate that it is possible to achieve functional recovery after complete spinal cord transection in pigs using a novel technology developed by our team. This technology includes a PEG-chitosan compound for fusing spinal cord tissue, a method for rapidly solidifying the compound using light, and several neuroprotection techniques.

這項研究的結果表明，使用團隊開發的新技術在豬的完全脊髓橫斷後，可以實現功能恢復。該技術包括用於融合脊髓組織的PEG-殼聚醣化合物，一種使用光快速固化該化合物的方法以及幾種神經保護技術。

The pigs in our study showed signs of recovery within two months of surgery, and by the end of the study period, they had regained significant mobility in their hind limbs. We are now working to further develop this technology for potential use in humans.

我們的研究中的豬表明，手術後兩個月內恢復了跡象，到研究期結束時，它們在後肢中恢復了顯著的活動能力。我們現在正在努力進一步開發這項技術，以便在人類中使用。

The HydraDAO proposal suggests that "revenue streams include specialized surgical kits priced between $3,500 and $20,000, depending on the market and region." Furthermore, the team would also provide "comprehensive training and certification for neurosurgeons and emergency medical services" personnel.

Hydradao提案建議“收入流包括專門的手術套件，價格在3500至20,000美元之間，具體取決於市場和地區。”此外，該團隊還將提供“神經外科醫生和緊急醫療服務的全面培訓和認證”。

Gumovski is a neurosurgery researcher based in Russia (Stavropol State Medical University and affiliated institutes). He was a member of Sergio Canavero’s research head-transplant project, cited in at least one relevant paper.

Gumovski是位於俄羅斯的神經外科研究人員（Stavropol州立醫科大學和附屬機構）。他是塞爾吉奧·卡納維羅（Sergio Canavero）的研究主管項目的成員，該項目至少在一份相關論文中引用。

Those articles were also published in Surgical Neurology International, while most top scientific publications shied away from the subject. The neurosurgeon from Turin, Italy, claimed to have performed a successful head transplant on a monkey back in 2016.

這些文章還發表在國際外科神經病學上，而大多數頂級科學出版物都避開了該主題。來自意大利都靈的神經外科醫生聲稱在2016年在猴子上進行了成功的頭部移植。

The team also experimented on human cadavers in preparation for a 2017 live human head transplant, which never took place. Neuroscientist Dean Burnett said at the time that head transplantation presented insurmountable challenges and that Canavero had “offered no feasible explanation or science for his claims to be able to overcome these hurdles.”

該團隊還對人體屍體進行了試驗，以準備2017年的現場人頭移植，這從未發生過。神經科學家迪恩·伯內特（Dean Burnett）當時說，頭部移植提出了無法克服的挑戰，而卡納維羅（Canavero）“沒有提供可行的解釋或科學，因為他的主張能夠克服這些障礙。”

While the Dowell team’s project builds on established research and should not be dismissed outrighthttps://decrypt.dev/assets/images/logos/crypto-logo.svg, it is hard not to notice the similarity in making public claims not unlike those that characterized Canavero’s career.

雖然Dowell團隊的項目基於既定研究，因此不應被駁回Outighthttps：//decrypt.dev/assets/images/logos/logos/crypto-logo.svg，但很難不注意到公開索賠與Canavero的職業相似。

Moreover, fusogens are well studied and less dramatic but similar results have been reported by other teams in the past (2019 example from the University of Texas).

此外，對熔融的研究和鮮明的研究不足，但過去的其他團隊（得克薩斯大學的2019年示例）報導了類似的結果。

The evidence provided is promising, but it is advisable to exercise caution, especially until multiple third-party teams independently reproduce the results.

提供的證據是有希望的，但建議謹慎行事，尤其是在多個第三方團隊獨立重現結果之前。

HydraDAO

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