Hydradao声称其研究人员能够使用一种新颖的技术来修复大鼠的棘突

在5月5日的帖子中，分散的科学（DESCI）项目Hydradao说，其研究项目之一导致“使脊椎完全转移的大鼠能够再次行走”。

Decentralized autonomous organization HydraDAO claims that its researchers were able to use a novel technique to repair severed spines in rats.

分散的自治组织Hydradao声称其研究人员能够使用一种新颖的技术来修复大鼠的棘突。

Decentralized science (DeSci) project HydraDAO said that one of its research projects resulted in rats who had their spines fully transected being able to walk again. More notably, recovery from surgery took five days.

去中心化科学（DESCI）计划Hydradao说，其中一项研究项目导致使脊柱完全转移的老鼠能够再次行走。更值得注意的是，从手术中恢复了五天。

The project in question is the Dowell spinal fusogens project led by Michael Lebenstein-Gumovski, which had 380,700 USDC donated to it. The dedicated HydraDAO page describes it as follows:

所讨论的项目是由迈克尔·勒本斯坦·古莫夫斯基（Michael Lebenstein-Gumovski）领导的Dowell Spinal Fusogens项目，该项目捐赠了380,700 USDC。专用的Hydradao页面将其描述如下：

A team of neuroscientists led by Dr. Michael Lebenstein-Gumovski developed a unique technology for fusing spinal cord tissue after complete transection. The project is named after the famous neurosurgeon Dr. Charles Dowell, a pioneer in spinal cord injury research.

由迈克尔·勒本斯坦·及多夫斯基（Michael Lebenstein-Gumovski）博士领导的一组神经科学家团队开发了一种独特的技术，用于融合脊髓组织后，完成后进行了融合。该项目以著名的神经外科医生查尔斯·道尔（Charles Dowell）博士的名字命名，他是脊髓损伤研究的先驱。

The technology is based on a special compound called PEG-chitosan, which is a derivative of polyethylene glycol (PEG) and chitosan, a biopolymer found in crustacean shells. This compound has been studied for its ability to fuse cell membranes, which is crucial for repairing severed nerve fibers.

该技术基于一种称为PEG-Chitosan的特殊化合物，该化合物是聚乙烯甘油（PEG）和壳聚糖的衍生物，这是甲壳类壳中发现的生物聚合物。该化合物的研究能力融合了细胞膜，这对于修复切开的神经纤维至关重要。

The researchers also developed a method for rapidly solidifying the PEG-chitosan compound using light, which allows them to create a strong scaffolding that can hold the spinal cord together as it heals.

研究人员还开发了一种使用光快速凝固PEG-Chitosan化合物的方法，这使他们能够创建强大的脚手架，可以将脊髓固定在一起。

In addition, they used several neuroprotection techniques, such as local hypothermia and cellular death inhibitors, to minimize damage to the nerve tissue during surgery.

此外，他们使用了几种神经保护技术，例如局部体温过低和细胞死亡抑制剂，以最大程度地减少手术中对神经组织的损害。

The results of the research are promising. Pigs that had their spines completely severed and were treated with the technology developed by Dr. Lebenstein-Gumovski's team recovered mobility within two months. The researchers are now working to further develop the technology and hope to begin human testing soon.

研究结果是有希望的。猪的猪完全切断，并接受了勒本斯坦·古莫夫斯基博士在两个月内恢复流动性的技术。研究人员现在正在努力进一步开发该技术，并希望尽快开始人类测试。

Fusogens are chemicals capable of fusing cell membranes and have long been researched as a means to reconnect severed nerve fibers. One such chemical is polyethylene glycol (PEG), which was shown to promote membrane fusion and seal axonal membranes in other research.

熔融剂是能够融合细胞膜的化学物质，长期以来一直研究为重新连接切断的神经纤维的一种手段。一种这样的化学物质是聚乙烯乙二醇（PEG），该乙二醇（PEG）在其他研究中被证明可促进膜融合和密封轴突膜。

Lebenstein-Gumovski's team adds a biopolymer from crustacean shells called chitosan, resulting in a PEG-chitosan compound dubbed neuro-PEG. This compound is also photopolymerizable, meaning it can be rapidly solidified using light.

Lebenstein-Gumovski的团队增加了一个名为Chitosan的甲壳类动物的生物聚合物，从而产生了一个名为Neuro-Peg的Peg-Chitosan化合物。该化合物也是可光聚合的，这意味着它可以使用光快速固化。

This presumably allows for creating a solid scaffolding that can weld the spinal cord more permanently than liquid PEG-based solutions. Dowell also implements neuroprotection techniques such as localized hypothermia and cellular death inhibitors to prevent further damage to nerve tissue.

据推测，与基于液体PEG的溶液相比，这可以创建可更永久焊接脊髓的实心脚手架。 Dowell还实现了神经保护技术，例如局部体温过低和细胞死亡抑制剂，以防止对神经组织的进一步损害。

A 2023 research paper by Gumovski published in the peer-reviewed scientific journal Surgical Neurology International claimed that pigs treated with the compound recovered mobility in two months. The study’s conclusion reads:

Gumovski的2023年研究论文发表在同行评审的科学杂志《外科神经病学》国际杂志上声称，用化合物恢复了两个月的流动性。该研究的结论是：

The results of this study demonstrate that it is possible to achieve functional recovery after complete spinal cord transection in pigs using a novel technology developed by our team. This technology includes a PEG-chitosan compound for fusing spinal cord tissue, a method for rapidly solidifying the compound using light, and several neuroprotection techniques.

这项研究的结果表明，使用团队开发的新技术在猪的完全脊髓横断后，可以实现功能恢复。该技术包括用于融合脊髓组织的PEG-壳聚糖化合物，一种使用光快速固化该化合物的方法以及几种神经保护技术。

The pigs in our study showed signs of recovery within two months of surgery, and by the end of the study period, they had regained significant mobility in their hind limbs. We are now working to further develop this technology for potential use in humans.

我们的研究中的猪表明，手术后两个月内恢复了迹象，到研究期结束时，它们在后肢中恢复了显着的活动能力。我们现在正在努力进一步开发这项技术，以便在人类中使用。

The HydraDAO proposal suggests that "revenue streams include specialized surgical kits priced between $3,500 and $20,000, depending on the market and region." Furthermore, the team would also provide "comprehensive training and certification for neurosurgeons and emergency medical services" personnel.

Hydradao提案建议“收入流包括专门的手术套件，价格在3500至20,000美元之间，具体取决于市场和地区。”此外，该团队还将提供“神经外科医生和紧急医疗服务的全面培训和认证”。

Gumovski is a neurosurgery researcher based in Russia (Stavropol State Medical University and affiliated institutes). He was a member of Sergio Canavero’s research head-transplant project, cited in at least one relevant paper.

Gumovski是位于俄罗斯的神经外科研究人员（Stavropol州立医科大学和附属机构）。他是塞尔吉奥·卡纳维罗（Sergio Canavero）的研究主管项目的成员，该项目至少在一份相关论文中引用。

Those articles were also published in Surgical Neurology International, while most top scientific publications shied away from the subject. The neurosurgeon from Turin, Italy, claimed to have performed a successful head transplant on a monkey back in 2016.

这些文章还发表在国际外科神经病学上，而大多数顶级科学出版物都避开了该主题。来自意大利都灵的神经外科医生声称在2016年在猴子上进行了成功的头部移植。

The team also experimented on human cadavers in preparation for a 2017 live human head transplant, which never took place. Neuroscientist Dean Burnett said at the time that head transplantation presented insurmountable challenges and that Canavero had “offered no feasible explanation or science for his claims to be able to overcome these hurdles.”

该团队还对人体尸体进行了试验，以准备2017年的现场人头移植，这从未发生过。神经科学家迪恩·伯内特（Dean Burnett）当时说，头部移植提出了无法克服的挑战，而卡纳维罗（Canavero）“没有提供可行的解释或科学，因为他的主张能够克服这些障碍。”

While the Dowell team’s project builds on established research and should not be dismissed outrighthttps://decrypt.dev/assets/images/logos/crypto-logo.svg, it is hard not to notice the similarity in making public claims not unlike those that characterized Canavero’s career.

虽然Dowell团队的项目基于既定研究，因此不应被驳回Outighthttps：//decrypt.dev/assets/images/logos/logos/crypto-logo.svg，但很难不注意到公开索赔与Canavero的职业相似，这是不可能的。

Moreover, fusogens are well studied and less dramatic but similar results have been reported by other teams in the past (2019 example from the University of Texas).

此外，对熔融的研究和鲜明的研究不足，但过去的其他团队（得克萨斯大学的2019年示例）报道了类似的结果。

The evidence provided is promising, but it is advisable to exercise caution, especially until multiple third-party teams independently reproduce the results.

提供的证据是有希望的，但建议谨慎行事，尤其是在多个第三方团队独立重现结果之前。

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