已確定與較高的 COVID-19 死亡率相關的基因變異

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Scientists Identify Genetic Variant Linked to Increased Mortality from COVID-19

科學家發現與 COVID-19 死亡率增加相關的基因變異

Researchers have identified a genetic variant that appears to increase the likelihood of severe outcomes from COVID-19, including death. The variant, known as the p.Leu210His variant, is located in a gene that codes for a protein involved in regulating the immune system.

研究人員發現了一種基因變異，它似乎會增加 COVID-19 導致嚴重後果（包括死亡）的可能性。該變異體被稱為 p.Leu210His 變異體，位於編碼參與調節免疫系統的蛋白質的基因中。

A recent study published in the journal Nature Genetics analyzed genetic data from over 2,000 patients with COVID-19. The results showed that individuals with the p.Leu210His variant were more likely to experience severe symptoms, require hospitalization, and succumb to the disease.

最近發表在《自然遺傳學》雜誌上的一項研究分析了 2000 多名 COVID-19 患者的遺傳數據。結果顯示，攜帶 p.Leu210His 變異的個體更有可能出現嚴重症狀、需要住院治療並死於該疾病。

"This finding suggests that genetic factors may play a role in determining the severity of COVID-19," said Dr. Mark Daly, lead author of the study. "It could also help identify high-risk individuals who may benefit from targeted preventive measures."

該研究的主要作者 Mark Daly 博士說：“這一發現表明遺傳因素可能在決定 COVID-19 的嚴重程度方面發揮作用。” “它還可以幫助識別可能受益於有針對性的預防措施的高風險人群。”

While the p.Leu210His variant remains relatively rare, the discovery highlights the potential importance of genetic testing in understanding and managing COVID-19. Further research is needed to determine the exact mechanisms by which the variant affects disease severity and to develop strategies to mitigate its effects.

雖然 p.Leu210His 變異體仍然相對罕見，但這項發現凸顯了基因檢測在理解和管理 COVID-19 方面的潛在重要性。需要進一步的研究來確定該變異影響疾病嚴重程度的確切機制，並制定減輕其影響的策略。